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Upper gastrointestinal bleed

Prevalence
Causes
Clinical features
Investigations
Therapy
Prevention
Prognosis
Prevention

Varices

Continue endoscopic ligation a or sclerotherapy a until varices are obliterated

Why?

  • Sclerotherapy reduces rebleeding and death, and is more effective than beta-blockers alone. a

Sclerotherapy to obliterate varices reduces rebleeding and death

Patient Treatment Comparison Outcome CER OR
(95% CI)
NNT
(95% CI)
recent variceal bleed a sclerotherapy non-active treatment rebleeding
 
65% 0.63
(0.49 to 0.79)
9
(6 to 18)
  sclerotherapy non-active treatment death
 
44% 0.77
(0.61 to 0.98)
16
(9 to 200)
  sclerotherapy beta-blockers rebleeding
 
58% 0.66
(0.50 to 0.88)
12
(6 to 410)

Expiry date: July 2003
Levels of Evidence used in grading these guides

Author   A   Townsend , CM   Ball
Reviewer   L   Friedman
CAT Writers   A   Townsend , CM   Ball , CJ   Wotton