Prevention

Continue giving proton-pump inhibitors for at least 8 weeks. ^a

Why?

• Both lansoprazole ^a and pantoprazole ^a heal ulcers more effectively than ranitidine.

Peptic ulcer: lansoprazole and pantoprazole heal ulcers more effectively than ranitidine

Patient	Treatment	Comparison	Outcome	CER	RBI (95% CI)	NNT (95% CI)
on long-term NSAIDs with gastric ulcers a	lansoprazole	ranitidine	healed ulcer at 8 weeks	53%	33% (10% to 61%)	6 (4 to 15)
duodenal ulcer a	pantoprazole	ranitidine	healed ulcer at 4 weeks	63%	43% (22% to 67%)	4 (3 to 6)