Prevention

Give H. pylori eradication therapy to infected patients ^a

Why?

• More ulcers heal ^a and fewer patients rebleed. ^a
• Eradication therapy is more effective than long-term ranitidine at healing ulcers. ^a

H.pylori eradication therapy helps heal ulcers

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
peptic ulcer a	H. pylori eradication therapy	no therapy	healing of peptic ulcer	91%	6.60 (4.10 to 10.6)	13 (12 to 14)

H.pylori eradication therapy reduces rebleeding

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
bleeding peptic ulcer a	H. pylori eradication therapy	no therapy	rebleeding at 10 months	29%	100%	4 (2 to 20)
bleeding peptic ulcer a	H. pylori eradication therapy	long-term ranitidine	recurrent ulcer at 12 months	9%	89% (17% to 99%)	15 (9 to 58)