Therapy

Do not treat frequent premature ventricular contractions with class Ic anti-arrhythmics in patients with a recent myocardial infarction  ^a

Why?

• Patients who receive flecainide or encainide are at increased risk of dying  ^a

Flecainide or encainide kills patients with a recent MI and frequent PVCs<

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
recent MI and frequent PVCs a	flecainide or encainide	placebo	death or cardiac arrest	3.5%	-140% (-270% to -53%)	21 (14 to 40)