Prevention

• propafenone 600 mg ^b

Why?

• It reduces symptomatic arrhythmias, without clearly causing intolerable side-effects, unlike 900mg propafenone daily. ^b

Paroxysmal SVT: propafenone reduces symptomatic arrhythmias

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
paroxysmal SVT or AF b	propafenone 600 mg	placebo	symptomatic arrhythmia at 3 months	71%	49% (29% to 64%)	3 (2 to 5)
	propafenone 900 mg	placebo	symptomatic arrhythmia at 3 months	63%	89% (72% to 96%)	2 (1 to 2)
	propafenone 900 mg	placebo	intolerable adverse events at 3 months	1.7%	-1600% (-12000% to -130%)	-4 (-7 to -3)