Prevention

Give an ACE inhibitor ^a with indapamide if tolerated.

Why?

• Patients at with a stroke or TIA within the previous 5 years who take perindopril with indapamide are less likely to have a stroke, myocardial infarction or die. ^a
• A few patients have to stop medication due to hypotension. ^a

Ramipril reduces death and cardiovascular complications in patients at high-risk for cardiovascular disease

Patient a	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
previous stroke or TIA within 5 years	perindopril and indapamide if tolerated	placebo	stroke at 3.8 years	14%	27% (16% to 36%)	27 (19 to 48)
			major vascular event at 3.8 years	20%	24% (15% to 32%)	21 (15 to 35)
			hospital admission at 3.8 years	44%	7% (2% to 12%)	32 (18 to 150)
			withdrawal due to hypotension at 3.8 years	1.0%	-120% (-43% to -240%)	-87 (-190 to -57)