Therapy

• diazepam ^a 0.15 mg/kg iv at 5 mg/min.  An alternative route is rectally; using larger doses ^a

Why?

• More patients who have 30 mg of diazepam compared with 20 mg rectally stop fitting ^a

Larger doses of diazepam stop more seizures

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
status epilepticus a	diazepam 30 mg	diazepam 20 mg	termination of seizures at 24 hours	29%	61% (14% to 82%)	2 (1 to 7)