Therapy

• lorazepam ^a s 0.1 mg/kg iv at 2 mg/min 

Why?

• It is faster than diazepam, phenobarbital (10 minutes faster) or phenytoin (25 minutes faster) at terminating seizures ^a
• It is better than phenytoin at terminating seizures, but is not clearly different than diazepam with or without phenytoin, or phenobarbital ^d

Lorazepam stops more seizures than phenytoin

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
status epilepticus a	lorazepam	phenytoin	termination of seizures at 60 minutes	42%	21% (1% to 37%)	8 (4 to 160)