Therapy

• lung involvement ^c
• sequestration syndromes ^d
• neurological involvement (stroke, TIA, fits) ^d  

Why?

• Children with sickle cell disease and lung infection, infarction or acute chest syndrome improve clinically following blood transfusion (NNT = 1 at 48 hours). ^c

Blood transfusions lead to clinical improvement

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
sickle cell disease and lung infection, infarction or acute chest syndrome c	blood transfusion	no blood transfusion	no clinical improvement at 48 hours	75%	100%	1 (1 to 3)