Clinical features

• weight loss ^c
• fever ^c

Why?

Weight loss and fever make malignant or granulomatous disease more likely

Patient	Target Disorder and Reference Standard	Diagnostic Test	LR+ (95% CI)	Post-test Probability	LR- (95% CI)	Post-test Probability
pleural effusion c (pre-test probability: 39%)	malignancy or granulomatous disease (culture or biopsy)	weight loss > 4.5 kg	4.2 (2.2 to 7.8)	73%	0.35 (0.21 to 0.60)	19%
		fever > 38°C	4.3 (1.5 to 12)	73%	0.73 (0.57 to 0.93)	32%