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Myocardial infarction

Prevalence
Clinical features
Differential diagnosis
Investigations
Therapy
Prevention
Prognosis
Therapy

Give an insulin-glucose infusion a for 24 hours followed by subcutaneous insulin, 4 times daily for at least 3 months to patients with an admission glucose > 11.0 mmol/l. a

Why?

  • Patients with an acute MI and an admission glucose > 11.0 mmol/l who receive an intensive insulin regimen compared with standard treatment are less likely to die. a

Intensive insulin treatment reduces mortality for patients with a glucose > 11.0 mmol/l.

Patient Treatment Comparison Outcome CER RRR
(95% CI)
NNT
(95% CI)
myocardial infarction and admission glucose >11.0 mmol/l a IV insulin infusion for 24 hours, followed by SC insulin 4 times daily for 3 months standard treatment death
at 3.4 years
44% 24%
(7% to 38%)
9
(5 to 33)

Expiry date: November 2003
Levels of Evidence used in grading these guides

Author   CM   Ball , N   Shenker
Reviewer   S   Straus
CAT Writers   CJ   Wotton , N   Shenker , B   Phillips , CM   Ball