Therapy

Why?

• Adding heparin to aspirin reduces the risk of dying slightly, but increases the risk of severe bleeding (requiring a transfusion). ^a
• The effect on stroke is unclear. ^a

Adding heparin to aspirin slightly reduces death and slightly increases severe bleeding

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
myocardial infarction a	aspirin and heparin	aspirin	death at months	9%	0.94 (0.9 to 1.0)	200 (120 to infinity)
		aspirin	severe bleeding at months	1.1%	1.4 (1.2 to 1.7)	-230 (-460 to -130)
myocardial infarction a	heparin	no heparin	any bleeding	16%	1.55 (1.21 to 1.98)	15 (9 to 36)