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Myocardial infarction

Prevalence
Clinical features
Differential diagnosis
Investigations
Therapy
Prevention
Prognosis
Therapy

Consider anticoagulating patients with anterior MI who do not receive thrombolysis. a

Why?

  • It reduces formation of mural thrombi and subsequent emboli. a

Anticoagulation and thrombolysis reduce mural thrombosis in anterior MI

Patient Treatment Comparison Outcome CER OR
(95% CI)
NNT
(95% CI)
anterior MI a anticoagulation placebo mural thrombus
at days
40% 0.32
(0.20 to 0.52)
4
(4 to 7)
  anticoagulation placebo emboli from mural thrombus
at days
2% 0.14
(0.04 to 0.52)
58
(52 to 110)
  thrombolysis placebo mural thrombus
at days
40% 0.48
(0.29 to 0.79)
6
(4 to 18)

Expiry date: November 2003
Levels of Evidence used in grading these guides

Author   CM   Ball , N   Shenker
Reviewer   S   Straus
CAT Writers   CJ   Wotton , N   Shenker , B   Phillips , CM   Ball