Therapy

Note:

• 1.1% of patients given thrombolysis will have a stroke (95% CI: 0.99% to 1.3%) ^b

• The risk of stroke is increased with ^b
  • severe hypertension
  • increasing age
  • heart failure
  • use of alteplase
  • an anterior myocardial infarction

Severe hypertension, increasing age, and heart failure increase the risk of a stroke post-thrombolysis

Patient	Prognostic Factor	Outcome	CER	OR (95% CI)	NNF+ (95% CI)
myocardial infarction b	alteplase (versus streptokinase) independent	stroke	1.1%	1.42 (1.09 to 1.84)	210 (110 to 1000)
	aged 60-70 years independent			1.67 (1.15 to 2.41)	130 (64 to 590)
	aged >70 independent			2.72 (1.85 to 4.00)	53 (31 to 110)
	anterior site of MI independent			1.38 (1.06 to 1.79)	240 (110 to 1500)
	Killip class 2 at admission independent			1.49 (1.10 to 2.03)	182 (87 to 890)
	Killip class 3 or 4 at admission independent			1.87 (1.14 to 3.09)	110 (45 to 660)
	diastolic blood pressure >110 mmHg independent			2.88 (1.11 to 7.49)	48 (15 to 810)