Therapy

Note:

• One in eight patients have moderate or severe bleeding after thrombolysis. (13%: 95% CI: 13% to 14%) ^a  
• 5.0% have a major bleed (95% CI: 3.9% to 6.0%) ^b
• Ocular haemorrhage is extremely rare (0.03%: 95% CI: 0.01% to 0.05%) ^c
• Few patients develop a cardiac tamponade following thrombolysis (1%: 95% CI: 0.03% to 2.02%) ^c
• The risk of major bleeding is increased with ^a
  • female sex
  • African ancestry
  • increasing age

Women, Africans and older patients are at increased risk of bleeding

Patient	Prognostic Factor	Outcome	CER	OR (95% CI)	NNF+ (95% CI)
myocardial infarction given thrombolysis a	female independent	moderate or severe bleeding at 30 days	7.8%	1.42 (1.31 to 1.53)	34 (27 to 46)
	African ancestry independent			1.33 (1.12 to 1.57)	29 (17 to 77)
	increasing age independent			1.30 (1.26 to 1.35)