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Myocardial infarction

Prevalence
Clinical features
Differential diagnosis
Investigations
Therapy
Prevention
Prognosis
Investigations
 

Use the following clinical prediction rule to rank your patient for risk of a myocardial infarction

If clinical finding not present, go onto next question a     LR
 (95% CI)
probability of MI 
(95% CI)
ST elevation or Q waves in 2 or more leads, not known to be old     22 
(17 to 27)
75% 
(70% to 79%)
                          . .
chest pain began 48 hours ago or more => ST-T changes of ischaemia or strain, not known to be old 2.0 
(1.5 to 2.9)
22% 
(15% to 28%)
                        no changes or old 0.12 
(0.076 to 0.19)
1.6% 
(0.9% to 2.4%)
          
previous history of angina or MI => ST- T changes of ischaemia or strain, not known to be old 2.6 
(2.0 to 3.2)
26% 
(21% to 31%)
                        longest pain episode < 1 hour 0.30 
(0.18 to 0.49)
4.0% 
(2.1% to 5.9%)
                        pain worse than prior angina or the same as a prior MI 0.92 
(0.65 to 1.3)
11% 
(7.6% to 15%)
.   pain not as bad 0.076 
(0.019 to 0.31)
1.0% 
(0.0% to 2.5%)
                             
pain radiates to neck, left shoulder or left arm => aged < 40 0.18 
(0.058 to 0.57)
2.4% 
(0.0% to 5.1%)
.   chest pain reproduced by palpation 0.093 
(0.013 to 0.67)
1.3% 
(0.0% to 3.7%)
                        pain radiates to back, abdomen or legs 0.60 
(0.25 to 1.5)
7.7% 
(1.2% to 14%)
.   chest pain stabbing 0.13 
(0.018 to 0.94)
1.8% 
(0.0% to 5.2%)
                      chest pain not stabbing 1.5 
(1.1 to 2.0)
17% 
(13 to 22%)
-        
ST- T changes of ischaemia or strain, not known to be old     2.3 
(1.7 to 3.3)
26% 
(19% to 33%)
         
no changes or old     0.15
 (0.099 to 0.22)
2.0% 
(1.2% to 2.8%)
 

Why?

  • A third of patients can be classified as low-risk (36%: 95% CI: 34% to 38%) - 1% will die in hospital (95% CI: 0.3% to 1.8%) and 0.4% have life-threatening complications (95% CI: 0.0% to 0.8%). a b

 

Expiry date: November 2003
Levels of Evidence used in grading these guides

Author   CM   Ball , N   Shenker
Reviewer   S   Straus
CAT Writers   CJ   Wotton , N   Shenker , B   Phillips , CM   Ball