Therapy

Why?

• Bowel motions are slightly reduced (roughly one less a day), but adverse effects are common (drowsiness, pain, nausea, fatigue, dizziness, headache, itching). ^a

Opiate anti- diarrhoeal drugs cause adverse effects

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNH (95% CI)
active ulcerative colitis a	diphenoxylate	placebo	adverse effects at 14 days	5.6%	-800% (-6300% to -27%)	2 (1 to 5)