Therapy

• ciprofloxacin in Crohn's disease  ^d
• metronidazole in ulcerative colitis ^d
• vancomycin ^d
• anti-tuberculous therapy for Crohn's disease ^a

Why?

• Vancomycin does not clearly prevent surgery or subsquent relapses in active Crohn's disease or ulcerative colitis. ^d
• Anti-TB therapy does not reduce stricture formation, surgery or steroid use in Crohn's disease. It also causes side-effects. ^a

Anti-tuberculosis therapy causes adverse effects

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNH (95% CI)
Crohn's disease a	anti-TB chemotherapy	placebo	adverse effects at 2 years	4.8%	-470% (-1700% to -75%)	5 (3 to 10)