Therapy

• ciprofloxacin in ulcerative colitis ^a
• metronidazole in perianal and colonic Crohn's disease ^a

Why?

• Ciprofloxacin reduces treatment failures and need for colectomy in ulcerative colitis. ^a
• Metronidazole improves symptoms, though does not clearly increase remission in perianal and colonic Crohn's disease. ^a

Ulcerative colitis: ciprofloxacin reduces treatment failure and colectomies

Patient	Treatmen	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
active ulcerative colitis a	ciprofloxacin for 6 months	placebo	treatment failure  ? months	44%	53% (5% to 76%)	4 (2 to 25)
			colectomy ? months	40%	61% (11% to 83%)	4 (2 to 17)