Prognosis

• increasing duration of the disease ^b
• a first-degree relative with colorectal cancer  ^b  

Why?

• The annual incidence of colorectal cancer increases with increasing duration of the disease. ^b
  • first 10 years: 0.2% (95% CI: 0.1% to 0.2%)
  • second 10 years: 0.7% (95% CI: 0.4% to 1.2%)
  • third 10 years: 1.2% (95% CI: 0.7% to 1.9%)

   

Ulcerative colitis: first-degree relative with colorectal cancer increases the risk of colorectal cancer

Outcome	Risk Factor	PEER	OR (95% CI)	NNH (95% CI)
colorectal cancer b	first-degree relative with colorectal cancer independent	6.7%	2.31 (1.06 to 5.14)	13 (5 to 270)