Prevention

There is no clear benefit from:

• budesonide or other steroids ^a
• cyclosporine ^b

Why?

• Steroids fail to reduce relapse rates. ^a
• Cyclosporine causes side-effects without clearly reducing relapse ^b

Crohn's disease: cyclosporine causes adverse effects

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
Crohn's disease in remission b	cyclosporine	placebo	withdrawal due to adverse effects at	3.3%	-350% (-1100% to -74%)	-9 (-20 to -6)