Prevention

For patients with frequent relapses ^d give weekly methotrexate ^a

Why?

• It reduces relapse in patients with chronically active disease who are currently in remission ^a

Weekly methotrexate helps maintain remission 

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
Crohn's disease a	weekly methotrexate	placebo	relapse at 10 months	61%	43% (6% to 65%)	4 (2 to 23)