Clinical features

Look for ^c

• tachycardia
• fever
• anaemia
• raised ESR 

Why?

The Truelove criteria can help rank disease severity

Disease severity c	Criteria
severe disease	≥6 motions a day with macroscopic blood
	fever > 37.8° C on 2 out of 4 days
	pulse > 90 beats/minute
	anaemia < 75% predicted
	ESR > 30 mm/hr
moderate	not severe or mild
mild	≤4 motions a day with no more than small amounts of macroscopic blood
	no fever
	pulse < 90 beats/minute
	anaemia not severe
	ESR ≤30 mm/hr

Severe clinical disease makes severe endoscopic disease slightly more likely

Patient	Target Disorder and Reference Standard	Diagnostic Test	LR+ (95% CI)	Post-test Probability	LR- (95% CI)	Post-test Probability
active ulcerative colitis c (pre-test probability: 54%)	severe colitis (endoscopy)	severe disease on Truelove criteria	1.6 (1.03 to 2.5)	65%	0.59 (0.37 to 0.95)	41%