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Inflammatory bowel disease

Prevalence
Clinical features
Differential Diagnosis
Investigations
Therapy
Prevention
Prognosis
Clinical features

First attack of colitis

Ask about diarrhoea

  • its duration c
  • number of bowel movements per day at onset c

Why?

Prolonged diarrhoea make inflammatory bowel disease more likely

Patient Target Disorder and
Reference Standard
Diagnostic Test LR+
(95% CI)
Post-test Probability LR-
(95% CI)
Post-test Probability
diagnosed with gastroenteritis c (pre-test probability: 11%) inflammatory bowel disease
(endoscopy, histology)
diarrhoea for > 14 days 8.6
(4.1 to 18)
52% 0.62
(0.45 to 0.85)
7%

 

Few bowel movements a day at onset make inflammatory bowel disease more likely

Patient Target Disorder and
Reference Standard
Diagnostic Test LR+
(95% CI)
Post-test Probability
colitis undergoing sigmoidoscopy c (pre-test probability: 50%) inflammatory bowel disease
(stool culture, histology, follow-up)
bowel movements < 4 per day at onset 15
(2.2 to 110)
94%
    4-6 per day at onset 3.9
(1.3 to 12)
79%
    7-9 per day at onset 0.37
(0.095 to 1.4)
27%
    10-12 per day at onset 0.26
(0.10 to 0.66)
20%
    >12 per day hr at onset 0.0
(0.0 to 0.15)
0%

Expiry date: July 2003
Levels of Evidence used in grading these guides

Author   CM   Ball
Reviewer   L   Friedman
CAT Writers   D   Ford , CM   Ball