Clinical features

• any weight loss ^a
• a family history of inflammatory bowel disease ^a

Why?

Weight loss or a family history makes inflammatory bowel disease slightly more likely

Patient	Target Disorder and Reference Standard	Diagnostic Test	LR+ (95% CI)	Post-test Probability	LR- (95% CI)	Post-test Probability
children with suspected inflammatory bowel disease a (pre-test probability: 42%)	inflammatory bowel disease (colonoscopy, histology)	weight loss or short stature	4.3 (2.0 to 9.3)	76%	0.65 (0.52 to 0.83)	32%
		family history of IBD (first or second degree relative)	2.4 (1.4 to 4.0)	64%	0.61 (0.45 to 0.83)	31%