Clinical features

• glycaemic control ^{a b} and HbA1c levels ^b
• any previous episodes of hypoglycaemia  ^b

Why?

• Frequently low blood glucose levels ^a or HbA1c ^b help predict patients at increased risk for hypoglycaemia

Diabetes: history of hypoglycaemia or a low HbA-1c increase the risk of hypoglycaemia

Patient	Prognostic Factor	Outcome	CER	OR (95% CI)	NNF+ (95% CI)
type 1 diabetes b	history of hypoglycaemia at 6.5 years independent	hypoglycaemia requiring assistance at 6.5 years	41% (38% to 45%)	1.33 (1.17 to 1.52)	14 (10 to 26)
	fall in HbA1c by 10% (at baseline of 9%) independent			1.53 (1.43 to 1.64)	9 (8 to 11)

Diabetes: poor glycaemia control may increases the risk of severe hypoglycaemia

Outcome	Risk Factor	PEER	OR (95% CI)	NNH (95% CI)
severe hypoglycaemia b	poor glycaemic control independent	30%	3.0 (1.0 to 9.0)	4 (2 to infinity)