Browse Guides  internal medicine  endocrine and metabolic disorders

Hypercalcaemia

Prevalence
Causes
Clinical features
Investigations
Therapy
Prevention
Prognosis
Investigations

PTH-related protein c

Why?

PTH-related protein can help diagnose malignancy but not safely exclude it

Patient Target Disorder and
Reference Standard		 Diagnostic Test LR+
(95% CI) 		Post-test Probability LR-
(95% CI) 		Post-test Probability
hypercalcaemia c
(pre-test probability: 47%) 		malignancy
(investigations) 		PTH-related protein detected 8.7
(4.0 to 19) 		89% 0.22
(0.13 to 0.37) 		25%

Expiry date: September 2004
Levels of Evidence used in grading these guides

Author   CM   Ball
Reviewer   S B   Ramirez
CAT Writers   CM   Ball , CJ   Wotton