Therapy

• a proton-pump inhibitor ^a

Why?

• Patients with non-cardiac retrosternal chest pain and gastroesophageal reflux on pH monitoring who take omeprazole have less chest pain. ^a

Omeprazole reduces non-cardiac chest pain with gastroesophageal reflux

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
non-cardiac chest pain and gastroesophageal reflux a	omeprazole	placebo	chest pain better at 2 months	5.6%	-1400% (-9900% to -120%)	1 (1 to 2)
			fewer days with chest pain at 2 months	44%	-83% (-220% to -4%)	3 (1 to 14)