Therapy

• sick sinus syndrome ^a  
• carotid sinus syndrome ^c  

Why?

• It reduces syncope and heart failure. ^a

Permanent pacemakers reduce syncope and heart failure in symptomatic sick sinus syndrome

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
symptomatic sick-sinus syndrome a	permanent pacemaker	no treatment	syncope at 4 years	23%	76% (-7.0% to 94%)	6 (3 to 66)
			overt heart failure at 4 years	17%	84% (-28% to 98%)	7 (4 to 130)