Therapy

• amiodarone ^a
• propafenone ^a
• quinidine ^a

Why?

• Amiodarone ^a , propafenone ^a , and quinidine ^a are all more effective than control at conversion to sinus rhythm.
• Amiodarone is more effective than quinidine at cardioversion. ^a  

Amiodarone, propafenone and quinidine can cardiovert chronic or paroxymsal AF

Patient a	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
persistent or paroxysmal AF	amiodarone	control	sinus rhythm at 24 hours	30%	5.7 (1.0 to 33.4)	2 (2 to infinity)
	propafenone	control	sinus rhythm at 24 hours	30%	4.6 (2.6 to 8.2)	3 (2 to 4)
	quinidine	control	sinus rhythm at 24 hours	30%	2.9 (1.2 to 7.0)	4 (2 to 25)

Amiodarone is more effective at cardioversion than quinidine.

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
persistent or paroxysmal AF a	quinidine	amiodarone	sinus rhythm at24 hours	30%	0.2 (0.1 to 0.9)	-5 (-46 to -4)