Therapy

•  ibutilide or oral dofetilide ^a  

Why?

• Ibutilide is more effective at cardioversion than placebo. ^a
• Dofetilide is more effective at cardioversion than placebo ^a  

Adjusted-dose warfarin reduces stroke and death, but increases the risk of major bleeds

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
paroxysmal or persistent AF a	ibutilide or dofetilide	control	sinus rhythm at 24 hours	9.2%	29.1 (9.8 to 86.1)	2 (1 to 2)

Dofetilide is more effective at cardioversion than placebo

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
chronic AF a	dofetilide	placebo	sinus rhythm at 24 hours	1.2%	1200% (75 to 8900%)	7 (5 to 12)
			sinus rhythm at 12 months	20	63% (-1 to 170%)	9 (5 to 84)