Therapy

Alternatives to amiodarone include disopyramide  ^a

Why?

• Disopyramide maintains sinus rhythm better than placebo following DC cardioversion, but adverse effects are common  ^a

Disopyramide is better than placebo at maintaining sinus rhythm following cardioversion

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
chronic AF a	disopyramide	placebo	sinus rhythm at 1 year	30%	79% (7% to 200%)	4 (2 to 23)
			adverse effects at 1 year	17%	-270% (-610% to -88%)	-2 (-4 to -2)