Evidence-based On-call

Atrial fibrillation

Prevention

Consider using sotalol - at least 120 mg twice daily ^a

Why?

Sotalol reduces recurrent symptomatic episodes compared with placebo ^a , but only at doses of at least 120 mg twice daily. ^a

Paroxysmal AF: sotalol reduces recurrent symptomatic episodes

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
symptomatic AF or flutter ^a	sotalol 120 mg twice daily	placebo	recurrent symptomatic episodes at 12 months	70%	27% (3% to 45%)	5 (3 to 43)