Prevention

Why?

• It reduces symptomatic arrhythmias compared with placebo ^a or quinidine without clearly causing adverse effects at doses up to 600 mg daily. ^a
• It is not clearly more effective than flecainide ^d or sotalol ^d

Paroxysmal or persistent AF: propafenone maintains sinus rhythm better than control

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
AF a	propafenone	control	sinus rhythm at months	30%	3.7 (2.4 to 5.7)	3 (2 to 5)

Paroxysmal AF: propafenone reduces attacks better than quinidine

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
paroxysmal AF and frequent attacks a	oral propafenone	quinidine	>75% reduction in attacks at 6 months	46%	-90% (-170% to -36%)	2 (2 to 4)