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Asthma exacerbation

Prevalence
Clinical features
Differential Diagnosis
Investigations
Therapy
Prevention
Prognosis
Prognosis

The risk of dying is increased in patients attending hospital with: b     
  • 1 or more life-threatening asthma attacks
  • psychosocial problems

The risk is increased in patients in the community with:

  • non-compliance with treatment  b
  • 1 or more life-threatening asthma attacks  b
  • 1 or more previous respiratory arrests  b
  • 1 or more hospital admission with asthma in last year  b  
  • 1 or more attendance to an emergency department with asthma in last year  b
  • 3 or more categories of asthma drug prescribed in last year  b
  • regular beta-agonist use  b

Note

Clinical features can help predict death from asthma

Outcome Risk Factor PEER OR
(95% CI)
NNH
(95% CI)
death from asthma (community) b 3 or more categories of asthma drug prescribed last year
  independent
0.0057% 3.0
(1.04 to 10.5)
8800 
(1900 to 440000)
  non-compliance with treatment    
independent
0.0057% infinity
(5.2 to infinity)
<180 
(1 to 4200)
  1 or more life threatening asthma attacks  
 independent
0.0057% infinity
(4.9 to infinity)
<180 
(1 to 4500)
  1 or more previous respiratory arrests    
independent
0.0057% infinity
(1.4 to infinity)
<180 
(1 to 44000)
  1 or more hospital admissions with asthma in last year  
 independent
0.0057% 16.0
(2.5 to 666)
1200 
(27 to 12000)
  1 or more attendance to an emergency department with asthma in last year    
independent
0.0057% 8.5
(2.0 to 75.9)
2300 
(240 to 18000)
  1 or more life threatening asthma attacks    
independent
0.0057% 3.8
(1.2 to 15.5)
360 
(70 to 5000)
  psychosocial problems  
independent
0.0057% 3.5
(1.004 to 13.7)
400 
(80 to 250000)

 

Expiry date: November 2003
Levels of Evidence used in grading these guides

Authors   B   Wong , CM   Ball
Reviewer   B R   O'Driscoll
CAT Writers   B   Wong , CM   Ball