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Warfarin

Starting treatment
Indications
Dosing and monitoring
Complications
Follow-up
Indications

Give warfarin for the following conditions:
  • venous thromboembolism a  
  • atrial fibrillation a  
  • heart valves a  
  • anti-phospholipid syndrome c  

using the following therapeutic ranges:

Therapeutic range  INR
Venous thromboembolism b   2.0 - 3.0
Venous thromboembolism with INR 2.0 - 3.0 d 3.0 - 4.5
Atrial fibrillation b 2.0 - 3.0
Biological heart valves a   2.0 - 3.0
Mechanical heart valves c   3.0 - 4.5
 

Determine your patient's potential risk of bleeding when anticoagulated before deciding if it is worthwhile. d
Score one point for each of the following risk factors a  

  • aged 65 or more 
  • history of stroke 
  • history of gastrointestinal bleed 
  • recent myocardial infarction, Hct < 30%, Cr > 133 µmol/l or diabetes mellitus

 Risk of major bleeding on anticoagulation therapy

Score a risk of major bleeding
0 low
1 or 2 medium
3 or 4 high

 

If warfarin is contraindicated, consider
  • a vena caval filter for deep vein thrombosis d
  • long term subcutaneous heparin d or LMWH d  

Expiry date: May 2003
Levels of Evidence used in grading these guides

With thanks to Drs. David Keeling, John Reynolds, David Sackett, Sharon Straus and Alan Townsend 
for use of their anticoagulation guide on which this one is based.

Author   CM   Ball
Reviewer   A   Gallus
CAT Writer   CM   Ball