Complications

Continue warfarin ^a and give 1 to 2 mg of vitamin K orally. ^a

Why?

• Vitamin K drops the INR < 5.0 faster than discontinuing warfarin ^a and leads to fewer bleeding episodes. ^a
• There is no clear difference in the INR range after nine days. ^a

Oral vitamin K lowers supratherapeutic INR levels faster than stopping warfarin

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
INR > 5.0 and no bleeding a	oral vitamin K 2 mg and continued warfarin	stop warfarin for 1 day	INR > 5.0 at 24 hours	46%	100%	2 (1 to 6)

Oral vitamin K lowers supratherapeutic INR levels faster than placebo and leads to fewer bleeding episodes

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
INR 4.5 to 10 and no bleeding a	oral vitamin K 1 mg	placebo	INR 1.8 to 3.2 at 24 hours	21%	170% (43% to 410%)	3 (2 to 6)
			bleeding episode  at 3 months	18%	76% (-9% to 95%)	7 (4 to 120)