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Warfarin

Starting treatment
Indications
Dosing and monitoring
Complications
Follow-up
Complications

Life-threatening bleed
  • Give a concentrate of factors II, VII, IX, and X at a dose of 50 units of factor IX per kg body weight c  

Why?

Factor concentrate reverses INR faster than fresh frozen plasma

Patient Treatment Comparison Outcome CER RRR
(95% CI)		 NNT
(95% CI)
urgent reversal of INR required c factor concentrate fresh frozen plasma INR 2.0 or less
at 15 minutes 		58% 66%
(2% to 168%) 		3
(1 to 10)


Expiry date: May 2003
Levels of Evidence used in grading these guides

With thanks to Drs. David Keeling, John Reynolds, David Sackett, Sharon Straus and Alan Townsend 
 for use of their anticoagulation guide on which this one is based.

Author   CM   Ball
Reviewer   A   Gallus
CAT Writer   CM   Ball