Therapy

There is no clear benefit from using a platelet glycoprotein IIb/ IIIa inhibitor alone. ^a

Why?

• Although patients given tirofiban are less likely to die, have an MI or refractory ischaemia at 48 hours, there is no clear benefit at 1 week or 1 month. ^a
• The risk of thrombocytopenia is increased. ^a

Tirofiban increases the risk of thrombocytopenia

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
unstable angina a	tirofiban	heparin	thrombocytopenia at 1 month	0.37%	-200% (-650% to -19%)	140 (75 to 660)