Therapy

Why?

• Ticlodipine reduces non-fatal myocardial infarction, although it has no clear effect on death from heart disease ^a    
• However, adverse effects severe enough to discontinue therapy are common (particularly neutropenia) ^a

Ticlopidine reduces non-fatal MI

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
unstable angina a	ticlodipine	no ticlodipine	non-fatal MI at 6 months	8.8%	46% (2.0% to 70%)	24 (13 to 390)