Therapy

Consider giving probucol ^a  

Why?

• Patients who take probucol following angioplasty are less likely to die, have a myocardial infarction or require revascularisation , but side effects (particularly diarrhoea) are common. ^a

Angioplasty: probucol reduces death, myocardial infarction and revascularisation.

Patient a	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
angioplasty	probucol	placebo	death, MI orevascularisation at 6 months	30%	47% (3% to 71%)	7 (4 to 86)
angioplasty	probucol	placebo	side-effects at 6 months	1.3%	-1100% (-8800% to -58%)	-7 (-18 to -5)