Therapy

Why?

• Adding a calcium-channel blocker reduces recurrent ischaemia ^a , myocardial infarction, need for surgery and sudden death. ^a

Adding calcium-channel blockers to a beta-blocker reduces recurrent ischaemia and myocardial infarction

Patient	Treatment	Comparison	Outcome	CER	RRR (95% CI)	NNT (95% CI)
unstable angina on a beta-blocker a	nifedipine	placebo	recurrent ischaemia at 48 hours	31%	46% (6% to 69%)	7 (4 to 58)
			MI, sudden death or need for surgery at weeks	61%	28% (1% to 48%)	6 (3 to 110)