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Acute coronary syndrome

Prevalence
Clinical features
Differential diagnosis
Investigations
Therapy
Prevention
Prognosis
Investigations
Arrange stress testing on discharge or as an outpatient using any of  a b
  • scintigraphy a b - look for a reversible perfusion defect b
Why?

Scintigraphy makes multivessel coronary artery disease more likely

Patient Target Disorder and
Reference Standard
Diagnostic Test LR+
(95% CI)
Post-test Probability LR-
(95% CI)
Post-test Probability
chest pain referred for further investigation
(pre-test probability: 52%) a
multivessel coronary artery disease
(coronary angiography)
scintigraphy 2.5
(1.5 to 4.2)
76% 0.44
(0.29 to 0.67)
36%
 

Scintigraphy : a reversible perfusion defect makes coronary artery disease more likely

Patient b Target Disorder and
Reference Standard
Diagnostic Test LR+
(95% CI)
Post-test Probability
suspected coronary artery disease
(pre-test probability: 51%) 
coronary artery stenosis
(coronary angiography)
scintigraphy: reversible perfusion defect 12
93%
    fixed perfusion defect 1.4
59%
    no perfusion defect 0.18
16%
 

Thallium scintigraphy can help diagnose restenosis following PTCA

Patient Target Disorder and
Reference Standard
Diagnostic Test LR+
(95% CI)
Post-test Probability LR-
(95% CI)
Post-test Probability
recent PTCA a  
(pre-test probability: 51%)
coronary artery re stenosis > 50%
(coronary angiography)
scintigraphy 3.9 80% 0.16 14%

 

 

Expiry date: June 2003
Levels of Evidence used in grading these guides

Authors   CM   Ball , N   Shenker
Reviewer   I K   Jang
CAT Writers   N   Shenker , CJ   Wotton , CM   Ball , RS   Phillips