Anaphylaxis

Prevalence Causes Clinical features Differential diagnosis Investigations Therapy Prevention Prognosis

Therapy Consider giving an antihistamine a.  Why? Patients who take diphenhydramine compared with cimitedine are more likely to have relief of symptoms. a  Combining ranitine with diphenhydramine helps urticaria settle. a  There is no clear benefit from adding cimetidine d  to diphenhydramine.    Patient Treatment Comparison Outcome CER RRR (95% CI) NNT (95% CI) acute allergic reaction  a diphenhydramine cimetidine no relief of symptoms  at 30 minutes 40% 100% 3 (1 to 10) acute allergic reaction  a ranitidine and diphenhydramine ranitidine urticaria or angoedema at 2 hours 54% 45% (8 to 68) 4 (2 to 22)

 

Expiry date: September 2004
Levels of Evidence used in grading these guides

Authors	M   Bennett , RS   Phillips
Reviewer	M   Daniel
CAT Writers	CM   Ball , M   Bennett