Therapy

Why?

• It is more effective than unfractionated heparin. ^a
• It causes fewer bleeds than unfractionated heparin. ^a
• It is as more cost-effective than intravenous unfractionated heparin. ^a

LMWH and warfarin reduces death and causes less bleeding than heparin and warfarin

Patient	Treatment	Comparison	Outcome	CER	OR (95% CI)	NNT (95% CI)
venous thromboembolism a	LMWH and warfarin	heparin and warfarin	death at 3-6 months	5.7%	0.74 (0.57 to 0.98)	59 (35 to 780)
			major bleed at 3-6 months	2.0%	0.55 (0.34 to 0.89)	115 (78 to 472)
cancer and venous thromboembolism a	LMWH and warfarin	heparin and warfarin	death at 3-6 months	24%	0.53 (0.33 to 0.85)	10 (7 to 35)