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Diabetic ketoacidosis

Prevalence
Causes
Clinical features
Investigations
Therapy
Prevention
Prognosis
Prevalence

Diabetic ketoacidosis is defined as d
  • hyperglycaemia (> 14 mmol/l)
  • metabolic acidosis (pH < 7.35 or bicarbonate < 15 mmol/l)
  • High anion gap (Anion gap = Na- + KHC0 3 ) c
  • ketonaemia

Hyperglycaemic hyperosmolar nonketosis is different: d

  • Blood glucose is higher (often > 33 mmol/l).
  • No acidosis
  • One plus ketonuria at the most on urine dipstick.
  • Higher Na (often > 150 mmol/l)
 

DKA is relatively common b in patients with diabetes and is often recurrent b
Roughly one in seven patients with hyperglycaemia who feel unwell have diabetic ketoacidosis.
Up to a quarter of cases are patients with new-onset diabetes. c  


Expiry date: May 2004
Levels of Evidence used in grading these guides

Author   C   Ball
Reviewer   N   Chi
CAT Writers   CM   Ball , C   Wotton