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Browse CATs  internal medicine  gastroenterology  upper gastrointestinal bleeding

Diagnosis Economics Harm/ aetiology Prognosis Therapy Peptic ulcers Varices

H. pylori a proton pump inhibitor plus 2 antibiotics was effective eradication therapy Level of evidence 2a Expiry Date November 2002 H. pylori a proton-pump inhibitor and 2 antibiotics are most effective at eradication Level of evidence 1a Expiry Date November 2002 NSAIDs GI injury: misoprostol decreases injury. Level of evidence 1a Expiry Date October 2002 Upper GI bleed balloon tamponade controlled bleeding faster, but caused more complications Level of evidence 1b Expiry Date October 2002 Upper GI bleed no clear benefit from immediate elective surgery Level of evidence 4 Expiry Date October 2002 Upper GI bleed non-variceal: somatostatin or octreotide reduces rebleeding and the need for surgery. Level of evidence 1a Expiry Date October 2002 Upper GI bleed tranexamic acid reduces mortality but not rebleeding or the need for surgery Level of evidence 1a Expiry Date January 2003 Upper GI bleed Diagnostic endoscopy had no effect on rebleeding or mortality Level of evidence 1b- Expiry Date October 2002 Upper GI bleed no clear benefit from cimetidine Level of evidence 1b- Expiry Date January 2003 Upper GI bleed omeprazole did not prevent rebleeding, need for surgery or death Level of evidence 1b Expiry Date January 2003 Upper GI bleeding rofecoxib reduced the risk compared with NSAIDs Level of evidence 1b Expiry Date December 2002 Upper GI bleeds second-look endoscopy had no clear effect on rebleeding. Level of evidence 1b- Expiry Date October 2002 Upper GI bleeds alcohol added to epinephrine had no clear effect. Level of evidence 1b- Expiry Date October 2002 Upper GI bleeds omeprazole improved outcome at 72 hours. Level of evidence 1b Expiry Date June 2003