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Diagnosis Harm/ aetiology Prognosis Therapy

Altered Mental Status Thiamine may cause few side effects if given as an i/v push Level of evidence 4 Expiry Date January 2004 Coma hypertonic saline is no better than lactated Ringer's solution. Level of evidence 1b- Expiry Date September 2003 Coma flumazenil reversed drug overdose. Level of evidence 1b Expiry Date November 2003 Coma flumazenil helped patients suspected of taking overdoses wake up Level of evidence 1b Expiry Date October 2003 Head injury hypothermia reduced death and severe disability Level of evidence 1a Expiry Date October 2003 Hypoglycaemia Intramuscular and intravenous glucagon were similar in effect Level of evidence 2b- Expiry Date August 2003 Hypoglycaemia Intravenous glucose restored consciousness more quickly than intravenous glucagon Level of evidence 1b Expiry Date August 2003 Hypoglycaemia Intravenous glucose produced a quicker return to consciousness than intramuscular glucagon Level of evidence 1b- Expiry Date August 2003 Overdose Flumazenil increased Glasgow Coma Score. Level of evidence 2b Expiry Date May 2003 Status epilepticus Lorazepam was effective and faster than other medications. Level of evidence 1b Expiry Date September 2003 Status epilepticus Lorazepam may be as good as diazepam for stopping seizures Level of evidence 1b Expiry Date September 2003 Traumatic brain injury no clear benefit from hyperventilation, mannitol, steroids, barbiturates or CSF drainage Level of evidence 1a- Expiry Date November 2003 Venous thromboembolism prophylaxis: antiplatelet drugs reduce the risk of DVT and PE in high risk medical and surgical patients. Level of evidence 1a Expiry Date September 2003